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Arsenal’s Theo Walcott, Santi Cazorla, Nacho Monreal and Hector Bellerin will miss the Champions League group game at Ludogorets Razgrad on Tuesday.
Walcott, Cazorla and Monreal each missed the Premier League win at Sunderland on Saturday through injury but Bellerin played the full match.
Striker Olivier Giroud and midfielder Aaron Ramsey came on as substitutes in that match and could start.
Midfielder Granit Xhaka, who was banned domestically, is also available.
Wenger set on top spot
Arsenal and Paris St-Germain both have seven points at the top of Group A – Ludogorets and Basel have one point.
“It’s our prime target to win the group,” said Wenger, whose team are second in the Premier League. “We have a home game with PSG to come so we have a good opportunity.”
The Gunners follow Tuesday’s match with a top-flight game against north London rival’s Tottenham on Sunday. They then face Manchester United and Bournemouth in the league as well as Southampton in the EFL Cup plus the fixture against PSG during a packed November.
“We have some very important games in front of us,” added Wenger.
“But we need to continue to do what we’ve done until now by just focusing on the next game. We have to try to win on Tuesday night and then we have Tottenham at home on Sunday.
“We’ve had difficult Novembers in previous seasons, but we’ve also had positive ones in our history too. The most important thing is to not live in the past, we have to live with the team we have at the moment.
“Our destiny lies in the minds of the players, how strong our focus is and how hungry we are. We need to be like that in every single game, starting on Tuesday.”
My time will come – Giroud
France striker Giroud has returned after being hampered by a toe injury and faces a battle to regain a regular starting place because of the form of Alexis Sanchez.
However, the 30-year-old scored two goals at the Stadium of Light on Saturday and could make his first start this season for Arsenal on Tuesday.
“I’m just concentrating on what I have to do on the pitch. My time will come,” said Giroud, who was sent off in Arsenal’s opening Champions League game against Paris St-Germain.
“Obviously I’d prefer to be on the pitch, but I came back late from the Euros. I was not fit enough to play first and then, unfortunately, after I had an annoying injury I needed to take my time to come back as soon as possible.”
He added: “We [he and Sanchez] can play together, we can play up front, or on our own.
“I hope to come back and work hard at training. But I’m happy as long as we win. We have a very good team cohesion.
“I’m not questioning myself too much about my place. I’m focused on the team.”